Gut Microbiota-mediated Alleviation of Dextran Sulfate Sodium-induced Colitis in Mice.

ABSTRACT:

Background and aims

Gut dysbiosis characterized by an imbalanced microbiota is closely involved in the pathogenesis of a widespread gastrointestinal inflammatory disorder, inflammatory bowel disease. However, it is unclear how the complex intestinal microbiota affects development or resistant of mucosal inflammation. Our aim was to investigate the impact of the gut microbiota on susceptibility in a mouse model of ulcerative colitis.

Methods

We compared the susceptibility to dextran sulfate sodium (DSS)-induced colitis of inbred BALB/c mice obtained from the 3 main distributors of laboratory animals in Japan. Clinical symptoms of the colitis and the faecal microbiota were assessed. Cohousing approach was used to identify whether the gut microbiota is a primary factor determin

SUBMITTER: Ikeda E 

PROVIDER: S-EPMC11308119 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature