TP53-associated early breast cancer: new observations from a large cohort.

ABSTRACT:

Background

A recent large, well-annotated international cohort of patients with Li-Fraumeni syndrome and early-stage breast cancer was examined for shared features.

Methods

This multicenter cohort study included women with a germline TP53 pathogenic or likely pathogenic variant and nonmetastatic breast cancer diagnosed between 2002 and 2022. Clinical and genetic data were obtained from institutional registries and clinical charts. Descriptive statistics were used to summarize proportions, and differences were assessed using χ2 or Wilcoxon rank sum tests. Metachronous contralateral breast cancer risk, radiation-induced sarcoma risk, and recurrence-free survival were analyzed using the Kaplan-Meier methodology.

Results

Among 227 women who met study criteria, the median

SUBMITTER: Sandoval RL 

PROVIDER: S-EPMC11308175 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature