Alcohol and colorectal cancer risk, subclassified by mutational signatures of DNA mismatch repair deficiency.

ABSTRACT:

Background

We examined whether the association between alcohol consumption and colorectal cancer (CRC) incidence was stronger for tumors with higher contributions of defective mismatch repair (dMMR)-related tumor mutational signatures.

Methods

We used data from 227 916 men and women who participated in the Nurses' Health Study (1980-2016), the Nurses' Health Study II (1991-2017), and the Health Professionals Follow-Up Study (1986-2016). Dietary data were collected every 4 years through validated food frequency questionnaires. Relative contributions of 2 defective mismatch repair-related tumor mutational signatures with single-based substitutions (c-dMMRa/SBS15 and c-dMMRb/SBS26) were quantified using whole-exome sequencing data in a subset of incident CRC patients. Duplicati

SUBMITTER: Fang A 

PROVIDER: S-EPMC11308185 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature