The use of master protocols for efficient trial design to evaluate radiotherapy interventions: a systematic review.

ABSTRACT: The aim of this review was to highlight why the use of master protocols trial design is particularly useful for radiotherapy intervention trials where complex setup pathways (including quality assurance, user training, and integrating multiple modalities of treatment) may hinder clinical advances. We carried out a systematic review according to Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines, reviewing the findings using a landscape analysis. Results were summarized descriptively, reporting on trial characteristics highlighting the benefits, limitations, and challenges of developing and implementing radiotherapy master protocols, with three case studies selected to explore these issues in more detail. Twelve studies were suitable for inclusion (4 plat

SUBMITTER: Gilbert A 

PROVIDER: S-EPMC11308198 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature