LRRK2 kinase activity is necessary for development and regeneration in Nematostella vectensis.

ABSTRACT:

Background

The starlet sea anemone, Nematostella vectensis, is an emerging model organism with a high regenerative capacity, which was recently found to possess an orthologue to the human Leucine Rich Repeat Kinase 2 (LRRK2) gene. Mutations in this gene are the most common cause of inherited Parkinson's Disease (PD), highlighting the importance of understanding its function. Despite two decades of research, however, the function of LRRK2 is not well established.

Methods

To investigate the function of LRRKs in Nematostella vectensis, we applied small molecule inhibitors targeting the kinase activity of LRRK2 to examine its function in development, homeostasis and regeneration in Nematostella vectensis.

Results

In vivo analyses inhibiting the kinase function of this enz

SUBMITTER: Holmes G 

PROVIDER: S-EPMC11308222 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature