A Systematic Review and Meta-analysis of Opioids vs Nonopioids in Acute Pancreatitis.

ABSTRACT:

Background and aims

Although abdominal pain is one of the major criteria to diagnose acute pancreatitis (AP), there are no standardized guidelines to treat this troublesome symptom in the hospital setting. The aims of the study are to conduct a meta-analysis and to assess the efficacy of nonopioids vs opioids for pain management in AP.

Methods

We searched the medical literature through May 2021 to identify randomized controlled trials that examined the efficacy of opioids with nonopioids in AP pain management. Efficacy was reported as odds ratio (OR) with 95% confidence intervals (CIs) of each comparison tested.

Results

We identified 7 eligible randomized controlled trials, containing 389 patients. No significant difference in terms of pain intensity at day 1 (OR 0.82

SUBMITTER: Nelson AD 

PROVIDER: S-EPMC11308224 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature