Molecular Signatures of Senescence in Periodontitis: Clinical Insights.

ABSTRACT: Most of the elderly population is afflicted by periodontal diseases, creating a health burden worldwide. Cellular senescence is one of the hallmarks of aging and associated with several chronic comorbidities. Senescent cells produce a variety of deleterious secretions, collectively termed the senescence-associated secretory phenotype (SASP). This disrupts neighboring cells, leading to further senescence propagation and inciting chronic inflammation, known as "inflammaging." Detrimental repercussions within the tissue microenvironment can trigger senescence at a younger age, accelerate biological aging, and drive the initiation or progression of diseases. Here, we investigated the biological signatures of senescence in healthy and diseased gingival tissues by assessing the levels of

SUBMITTER: Rattanaprukskul K 

PROVIDER: S-EPMC11308264 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature