TetR family regulator AbrT controls lincomycin production and morphological development in Streptomyces lincolnensis.

ABSTRACT:

Background

The TetR family of transcriptional regulators (TFRs), serving as crucial regulators of diverse cellular processes, undergo conformational changes induced by small-molecule ligands, which either inhibit or activate them to modulate target gene expression. Some ligands of TFRs in actinomycetes and their regulatory effects have been identified and studied; however, regulatory mechanisms of the TetR family in the lincomycin-producing Streptomyces lincolnensis remain poorly understood.

Results

In this study, we found that AbrT (SLCG_1979), a TetR family regulator, plays a pivotal role in regulating lincomycin production and morphological development in S. lincolnensis. Deletion of abrT gene resulted in increased lincomycin A (Lin-A) production, but delayed mycelium for

SUBMITTER: Xu Y 

PROVIDER: S-EPMC11308395 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature