Antibacterial action of penicillin against Mycobacterium avium complex.

ABSTRACT:

Introduction

β-lactam antibiotics are promising treatments for Mycobacterium avium complex (MAC) lung disease. We hypothesized that benzylpenicillin has efficacy against MAC.

Methods

Benzylpenicillin lung concentration-time profiles of seven doses in three dosing schedules were administered for 28 days using the hollow fiber system model of intracellular MAC (HFS-MAC). Data were analyzed using the inhibitory sigmoid maximal effect (E_max) model for each sampling day, while two ordinary differential equations (ODEs) were used for the wild-type and penicillin-resistant mutants.

Results

Benzylpenicillin killed >2.1 log₁₀ colony-forming unit (CFU)/mL below Day 0, better than azithromycin, ethambutol, and rifabutin. Efficacy was terminated by ac

SUBMITTER: Deshpande D 

PROVIDER: S-EPMC11308404 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature