Microbiota alterations in patients treated for susceptible or drug-resistant TB.

ABSTRACT:

Background

We investigated alterations of human microbiota under anti-TB therapies in relationship to the level of Mycobacterium tuberculosis drug response.

Methods

Stool, sputum, and oral swab samples were analysed from participants with treatment-naïve TB and participants treated for drug-susceptible TB (DS-TB), drug-resistant TB without injectable drugs (DR-TB-inj-), or with injectable drugs (DR-TB-inj+) at 27-42 days of therapy.

Results

From September 2018 to December 2019, 5 participants with treatment-naïve TB, 6 participants with DS-TB, 10 participants with DR-TB-inj-, and 4 participants with DR-TB-inj+ were recruited. Reduced alpha diversities in stool samples indicated more profound dysbiosis in participants treated for DR-TB than in participants treat

SUBMITTER: Hauptmann M 

PROVIDER: S-EPMC11308407 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature