FOSL1-mediated LINC01566 negatively regulates CD4⁺ T-cell activation in myasthenia gravis.

ABSTRACT:

Background

Myasthenia gravis (MG) is an autoimmune disease characterized by pathogenic antibodies that target structures of the neuromuscular junction. The evidence suggests that the regulation of long noncoding RNAs (lncRNAs) that is mediated by transcription factors (TFs) plays a key role in the pathophysiology of MG. Nevertheless, the detailed molecular mechanisms of lncRNAs in MG remain largely undetermined.

Methods

Using microarray analysis, we analyzed the lncRNA levels in MG. By bioinformatics analysis, LINC01566 was found to potentially play an important role in MG. First, qRT‒PCR was performed to verify the LINC1566 expressions in MG patients. Then, fluorescence in situ hybridization was conducted to determine the localization of LINC01566 in CD4 + T cells. Finally,

SUBMITTER: Li L 

PROVIDER: S-EPMC11308467 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature