CD74 facilitates immunotherapy response by shaping the tumor microenvironment of hepatocellular carcinoma.

ABSTRACT:

Background

CD74 is ectopically expressed in many tumors and can regulate tumor immunity. However, there are many gaps in the study of the prognostic value of CD74 expression and immune infiltration in hepatocellular carcinoma (HCC).

Methods

An online tumor database was searched to obtain data on gene/protein expression. Immune infiltration analysis was performed using the Tumor Immune Estimation Resource and Comprehensive Analysis on Multi-Omics of Immunotherapy in Pan-cancer databases. Single-cell data were obtained from the Tissue-specific Gene Expression and Regulation, Single-cell Transcriptomes of Tumor Immune Microenvironment and Tumor Immune Single-cell Hub 2 databases.

Results

CD74 was highly expressed in HCC patients. HCC patients with high CD74 expression wh

SUBMITTER: Cheng J 

PROVIDER: S-EPMC11308498 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature