Peripheral endocannabinoids in major depressive disorder and alcohol use disorder: a systematic review.

ABSTRACT:

Background

Major Depressive Disorder (MDD) and Alcohol Use Disorder (AUD) are two high-prevalent conditions where the Endocannabinoid system (ECS) is believed to play an important role. The ECS regulates how different neurotransmitters interact in both disorders, which is crucial for controlling emotions and responses to stress and reward stimuli. Measuring peripheral endocannabinoids (eCBs) in human serum and plasma can help overcome the limitations of detecting endocannabinoid levels in the brain. This systematic review aims to identify levels of peripheral eCBs in patients with MDD and/or AUD and find eCBs to use as diagnostic, prognostic biomarkers, and potential therapeutic targets.

Methods

We conducted a systematic literature search according to the Preferred Reporting

SUBMITTER: Fuentes JJ 

PROVIDER: S-EPMC11308641 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature