Sex differences in pediatric sepsis-a systematic review protocol.

ABSTRACT:

Background

Pediatric sepsis remains a leading cause of childhood morbidity and mortality worldwide. Despite advancements in modern medicine, it accounts for more than 3 million childhood deaths per year. Multiple studies have emphasized that sex and gender have an impact on the treatment and outcome of various diseases. Adult studies have revealed sex differences in pathophysiological responses to septic shock, as well as a possible protective effect of estrogens on critical illness. Sex-specific maturational and developmental differences in host immunology have been previously demonstrated for neonatal and pediatric age groups. At present, there are no studies assessing the impact of sex on outcomes of children with sepsis.

Methods

The goal of this study is to assess sex-sp

SUBMITTER: Kennedy U 

PROVIDER: S-EPMC11308706 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature