The role of coffee and potential mediators in subclinical atherosclerosis: insights from Mendelian randomization study.

ABSTRACT:

Background and aims

Coffee contains many bioactive compounds, and its inconsistent association with subclinical atherosclerosis has been reported in observational studies. In this Mendelian randomization study, we investigated whether genetically predicted coffee consumption is associated with subclinical atherosclerosis, as well as the role of potential mediators.

Methods

We first conducted a two-sample Mendelian randomization analysis to examine the causal effect of coffee and its subtypes on subclinical atherosclerosis inferred from coronary artery calcification (CAC). Next, the significant results were validated using another independent dataset. Two-step Mendelian randomization analyses were utilized to evaluate the causal pathway from coffee to subclinical atherosclero

SUBMITTER: Yang Q 

PROVIDER: S-EPMC11309031 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature