Current Fluid Management Practice in Critically Ill Adults on Continuous Renal Replacement Therapy: A Binational, Observational Study.

ABSTRACT:

Introduction

In critically ill patients undergoing continuous renal replacement therapy (CRRT), a positive fluid balance (FB) is associated with adverse outcomes. However, current FB management practices in CRRT patients are poorly understood. We aimed to study FB and its components in British and Australian CRRT patients to inform future trials.

Methods

We obtained detailed electronic health record data on all fluid-related variables during CRRT and hourly FB for the first 7 days of treatment.

Results

We studied 1,616 patients from three tertiary intensive care units (ICUs) in two countries. After the start of CRRT, the mean cumulative FB became negative at 31 h and remained negative over 7 days to a mean nadir of -4.1 L (95% confidence interval (CI) of -4.6 to -3.5)

SUBMITTER: White KC 

PROVIDER: S-EPMC11309063 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature