More is different: progressive β-thiolation induced-porphyrin aggregation switches singlet oxygen photosensitization.

ABSTRACT: Incorporating sulfur atoms into photosensitizers (PSs) has been well-established to populate triplet states and increase singlet oxygen (¹O₂) production when exposed to light. In this work, we found that progressive thiolation of porphyrin β-periphery does promote intersystem crossing (ISC) between triplets and singlets, as seen in the excited state dynamics in dichloromethane or PS nanoparticles in water. However, in the latter case, more sulfur substitution deactivates ¹O₂ photosensitization, in contrast to the expected trend observed in dichloromethane. This observation was further supported by photocytotoxicity studies, where ¹O₂ photosensitization was switched off in living cells and multicellular spheroids despite bein

SUBMITTER: Zhu M 

PROVIDER: S-EPMC11309087 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature