Phenotypic and Functional Outcomes in Macrophages Exposed to an Environmentally Relevant Mixture of Organophosphate Esters in Vitro.

ABSTRACT:

Background

Organophosphate esters (OPEs) are flame retardants and plasticizers used in consumer products. OPEs are found ubiquitously throughout the environment with high concentrations in indoor house dust. Exposure to individual OPEs is associated with immune dysfunction, particularly in macrophages. However, OPEs exist as complex mixtures and the effects of environmentally relevant mixtures on the immune system have not been investigated.

Objectives

The objectives of this study were to evaluate the toxicity of an environmentally relevant mixture of OPEs that models Canadian house dust on macrophages using phenotypic and functional assessments in vitro.

Methods

High-content live-cell fluorescent imaging for phenotypic biomarkers of toxicity in THP-1 macrophag

SUBMITTER: Giles BH 

PROVIDER: S-EPMC11309092 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature