A combination of topical and systemic administration of brimonidine is neuroprotective in the murine optic nerve crush model.

ABSTRACT: Glaucoma is a multifactorial optic neuropathy that primarily affecting retinal ganglion cells (RGC). Brimonidine is an intraocular pressure-lowering drug with reported neuroprotective properties. This study aimed to compare the neuroprotective effects of topical and intraperitoneal (IP) brimonidine on RGCs from different retinal segments in a murine optic nerve crush (ONC) model.

Methods

forty-one Balb/c mice underwent unilateral ONC and were divided into three study groups: fifteen animals received saline drops twice per day and two additional IP injections of saline; fourteen mice received brimonidine drops twice per day; and 12 mice received brimonidine eye drops twice per day and two additional IP brimonidine injections. Animals were sacrificed seven days post-ONC, and immunohis

SUBMITTER: Maciulaitiene R 

PROVIDER: S-EPMC11309405 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature