Changes in the clinical course and prognosis of ulcerative colitis in Chinese populations: a retrospective cohort study.

ABSTRACT:

Background/aims

Data on the natural course of Chinese patients with ulcerative colitis (UC) was lacking. This study aimed to evaluate the natural history and prognosis of patients with UC in the past 15 years in China.

Methods

This cohort study included patients with UC in a tertiary hospital in southern China from 2007 to 2021 (cohort I: 2007-2011, cohort II: 2012-2016, cohort III: 2017-2021). Patients' clinical characteristics and natural history were analyzed retrospectively.

Results

Of 1,139 included patients, 683 patients presented with proctitis or left-sided colitis at diagnosis and 38.5% of them (263/683) developed proximal disease extension. Fifty-eight percent of patients experienced relapse, chronic continuous and intermittent active course. Five patients (

SUBMITTER: Liu X 

PROVIDER: S-EPMC11309821 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature