Impacts of tumor microenvironment during neoadjuvant chemotherapy in patients with esophageal squamous cell carcinoma.

ABSTRACT: With the advent of immune checkpoint inhibitors (ICIs), a better understanding of tumor microenvironment (TME) is becoming crucial in managing esophageal squamous cell carcinoma (ESCC) patients. We investigated the survival impact of TME status and changes in patients with ESCC who underwent neoadjuvant chemotherapy (NAC) followed by surgery (n = 264). We examined immunohistochemical status (CD4⁺, CD8⁺, CD20⁺, Foxp3⁺, HLA class-1⁺, CD204⁺, and programmed death ligand-1 [PD-L1⁺]) on 264 pre-NAC and 204 paired post-NAC specimens. Patients were classified by their pre- and post-NAC immune cell status and their changes following NAC. Our findings showed that pre-NAC TME status was not significantly associated with sur

SUBMITTER: Sugawara K 

PROVIDER: S-EPMC11309932 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature