Skeletal dysmorphology and mineralization defects in Fgf20 KO mice.

ABSTRACT:

Introduction

Fibroblast growth factor 20 (Fgf20), a member of the Fgf9 subfamily, was identified as an important regulator of bone differentiation and homeostasis processes. However, the role of Fgf20 in bone physiology has not been approached yet. Here we present a comprehensive bone phenotype analysis of mice with functional ablation of Fgf20.

Methods

The study conducts an extensive analysis of Fgf20 knockout mice compared to controls, incorporating microCT scanning, volumetric analysis, Fgf9 subfamily expression and stimulation experiment and histological evaluation.

Results

The bone phenotype could be detected especially in the area of​ the lumbar and caudal part of the spine and in fingers. Regarding the spine, Fgf20^-/- mice exhibited adhesions of the

SUBMITTER: Dlugosova S 

PROVIDER: S-EPMC11310068 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature