IBSP Promotes Breast Cancer Bone Metastasis and Proliferation via BMP-SMAD Signaling Pathway.

ABSTRACT:

Background

Integrin-Binding Sialoprotein (IBSP) has been implicated in tumor progression across various cancers. However, the specific role of IBSP in breast cancer remains underexplored. There is a need to investigate the mechanisms by which IBSP influences breast cancer progression and its potential as a therapeutic target.

Aims

This study aims to elucidate the role of IBSP in breast cancer, particularly its impact on tumor progression and its relationship with prognosis. We also seek to understand the underlying mechanisms, including the involvement of the BMP-SMAD signaling pathway, and to explore the potential of targeting IBSP for therapeutic interventions.

Methods and results

Overexpression of IBSP in breast cancer cells led to increased migration and invasion,

SUBMITTER: Ding W 

PROVIDER: S-EPMC11310091 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature