Prevalence of monoclonal gammopathy of undetermined significance in Eswatini: a population-based study in Africa.

ABSTRACT:

Background

Although monoclonal gammopathy of undetermined significance (MGUS) and multiple myeloma disproportionately affect Black individuals, few epidemiological studies have been conducted on these plasma cell disorders in Africa. Here we describe the prevalence of MGUS in Eswatini and compare our results to the landmark Olmsted County, Minnesota study.

Methods

Between 2016 and 2017, 13 339 residents of Eswatini participated in the Swaziland HIV Incidence Measurement Survey, from which a nationally representative biorepository was created. Plasma samples were then randomly selected and analyzed for MGUS. MGUS prevalence in Eswatini was compared with that of Olmsted County. In addition, demographic and HIV-related associations with MGUS were assessed.

Results

Of the

SUBMITTER: Cicero KI 

PROVIDER: S-EPMC11310106 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature