The histone methyltransferase KMT2D is essential for embryo implantation via regulating precise differentiation of endometrial cells.

ABSTRACT: Embryo implantation failures are a major challenge in reproductive medicine, but the underlying mechanism remains poorly understood. Successful implantation requires dynamic remodeling of the endometrium through integrated proliferation and differentiation of endometrial cells including luminal epithelial, glandular epithelial, and stromal cells. Conversely, their disruption causes infertility. Spatiotemporal control of transcription is required for these processes; however, the underlying epigenetic regulation is largely unknown. In this study, we examined expression data from the human endometrium during implantation and discovered that expression of the histone lysine methyltransferase KMT2D was significantly suppressed in patients with recurrent implantation failure. Further study reve

SUBMITTER: Kobayashi R 

PROVIDER: S-EPMC11310208 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature