Exposure to normobaric hypoxia shapes the acute inflammatory response in human whole blood cells in vivo.

ABSTRACT: Cells of the immune defence, especially leukocytes, often have to perform their function in tissue areas that are characterized by oxygen deficiency, so-called hypoxia. Physiological hypoxia significantly affects leukocyte function and controls the innate and adaptive immune response mainly through transcriptional gene regulation via the hypoxia-inducible factors (HIFs). Multiple pathogens including components of bacteria, such as lipopolysaccharides (LPS) trigger the activation of leukocytes. HIF pathway activation enables immune cells to adapt to both hypoxic environments in physiological and inflammatory settings and modulates immune cell responses through metabolism changes and crosstalk with other immune-relevant signalling pathways. To study the mutual influence of both processes in

SUBMITTER: Schonberger T 

PROVIDER: S-EPMC11310243 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature