Altered expression and localization of nuclear envelope proteins in a prostate cancer cell system.

ABSTRACT:

Background

The nuclear envelope (NE), which is composed of the outer and inner nuclear membranes, the nuclear pore complex and the nuclear lamina, regulates a plethora of cellular processes, including those that restrict cancer development (genomic stability, cell cycle regulation, and cell migration). Thus, impaired NE is functionally related to tumorigenesis, and monitoring of NE alterations is used to diagnose cancer. However, the chronology of NE changes occurring during cancer evolution and the connection between them remained to be precisely defined, due to the lack of appropriate cell models.

Methods

The expression and subcellular localization of NE proteins (lamins A/C and B1 and the inner nuclear membrane proteins emerin and β-dystroglycan [β-DG]) during prostate ca

SUBMITTER: Sandoval A 

PROVIDER: S-EPMC11310284 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature