Printed polymer platform empowering machine-assisted chemical synthesis in stacked droplets.

ABSTRACT: Efficiently exploring organic molecules through multi-step processes demands a transition from conventional laboratory synthesis to automated systems. Existing platforms for machine-assistant synthetic workflows compatible with multiple liquid-phases require substantial engineering investments for setup, thereby hindering quick customization and throughput increasement. Here we present a droplet-based chip that facilitates the self-organization of various liquid phases into stacked layers for conducting chemical transformations. The chip's precision polymer printing capability, enabled by digital micromirror device (DMD)-maskless photolithography and dual post-chemical modifications, allows it to create customized, sub-10 µm featured patterns to confine diverse liquids, regardless of densi

SUBMITTER: Sun Y 

PROVIDER: S-EPMC11310347 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature