Construction and validation of prognostic signatures related to mitochondria and macrophage polarization in gastric cancer.

ABSTRACT:

Background

Increasing evidence reveals the involvement of mitochondria and macrophage polarisation in tumourigenesis and progression. This study aimed to establish mitochondria and macrophage polarisation-associated molecular signatures to predict prognosis in gastric cancer (GC) by single-cell and transcriptional data.

Methods

Initially, candidate genes associated with mitochondria and macrophage polarisation were identified by differential expression analysis and weighted gene co-expression network analysis. Subsequently, candidate genes were incorporated in univariateCox analysis and LASSO to acquire prognostic genes in GC, and risk model was created. Furthermore, independent prognostic indicators were screened by combining risk score with clinical characteristics, and a

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC11310369 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature