A metabolic reprogramming-related gene signature correlates with prognosis and proliferation of BLCA.

ABSTRACT: Bladder cancer (BLCA) is one of the most frequent urothelium carcinoma, but with poor prognosis due to lack of reliable predictive biomarkers. Metabolic reprogramming involving in various nutrients, and is reported to be closely associated with malignant progression in BLCA. With the use of transcriptome sequencing data profiles of 349 patients from The Cancer Genome Atlas, we established a three-gene glycolysis-related signature to predict the prognosis of BLCA patients. Our signature constructed on the basis of AK3, GALK1 and NUP205 expression, detail features and interactions between these three genes were further explored. We established a nomogram by integrating clinical variables and the risk score. Glycolytic level and proliferation ability were detected to study the role and mechan

SUBMITTER: Wu Y 

PROVIDER: S-EPMC11310377 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature