Consistent viral evolutionary changes associated with the progression of human immunodeficiency virus type 1 infection.

ABSTRACT: To understand the high variability of the asymptomatic interval between primary human immunodeficiency virus type 1 (HIV-1) infection and the development of AIDS, we studied the evolution of the C2-V5 region of the HIV-1 env gene and of T-cell subsets in nine men with a moderate or slow rate of disease progression. They were monitored from the time of seroconversion for a period of 6 to 12 years until the development of advanced disease in seven men. Based on the analysis of viral divergence from the founder strain, viral population diversity within sequential time points, and the outgrowth of viruses capable of utilizing the CXCR4 receptor (X4 viruses), the existence of three distinct phases within the asymptomatic interval is suggested: an early phase of variable duration during which li

SUBMITTER: Shankarappa R 

PROVIDER: S-EPMC113104 | biostudies-literature | 1999 Dec

REPOSITORIES: biostudies-literature