Deoxygenative radical cross-coupling of C(sp³)-O/C(sp³)-H bonds promoted by hydrogen-bond interaction.

ABSTRACT: Building C(sp³)-rich architectures using simple and readily available starting materials will greatly advance modern drug discovery. C(sp³)-H and C(sp³)-O bonds are commonly used to strategically disassemble and construct bioactive compounds, respectively. However, the direct cross coupling of these two chemical bonds to form C(sp³)-C(sp³) bonds is rarely explored in existing literature. Conventional methods for forming C(sp³)-C(sp³) bonds via radical-radical coupling pathways often suffer from poor selectivity, severely limiting their practicality in synthetic applications. In this study, we present a single electron transfer (SET) strategy that enables the cleavage of amine α-C - H bonds and heterobenzylic C - O

SUBMITTER: Wang Y 

PROVIDER: S-EPMC11310525 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature