Human serum proteomics reveals a molecular signature after one night of sleep deprivation.

ABSTRACT:

Study objectives

Sleep deprivation is highly prevalent and caused by conditions such as night shift work or illnesses like obstructive sleep apnea. Compromised sleep affects cardiovascular-, immune-, and neuronal systems. Recently, we published human serum proteome changes after a simulated night shift. This pilot proteomic study aimed to further explore changes in human blood serum after 6 hours of sleep deprivation at night.

Methods

Human blood serum samples from eight self-declared healthy females were analyzed using Orbitrap Eclipse mass spectrometry (MS-MS) and high-pressure liquid chromatography. We used a within-participant design, in which the samples were taken after 6 hours of sleep at night and after 6 hours of sleep deprivation the following night. Systems biolog

SUBMITTER: Bjorkum AA 

PROVIDER: S-EPMC11310596 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature