Estimating the Seroincidence of Scrub Typhus using Antibody Dynamics after Infection.

ABSTRACT: Scrub typhus, a vector-borne bacterial infection, is an important but neglected disease globally. Accurately characterizing the burden is challenging because of nonspecific symptoms and limited diagnostics. Prior seroepidemiology studies have struggled to find consensus cutoffs that permit comparisons of estimates across contexts and time. In this study, we present a novel approach that does not require a cutoff and instead uses information about antibody kinetics after infection to estimate seroincidence. We use data from three cohorts of scrub typhus patients in Chiang Rai, Thailand, and Vellore, India, to characterize antibody kinetics after infection and two population serosurveys in the Kathmandu Valley, Nepal, and Tamil Nadu, India, to estimate seroincidence. The samples were tested

SUBMITTER: Aiemjoy K 

PROVIDER: S-EPMC11310618 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature