Association Between Particulate Matter Exposure and Preterm Birth in Women With Abnormal Preconception Thyrotropin Levels: Large Cohort Study.

ABSTRACT:

Background

Prior research has linked exposure to particulate matter with an aerodynamic diameter of ≤2.5 μm (PM2.5) with preterm birth (PTB). However, the modulating effect of preconception thyroid stimulating hormone (TSH) levels on the relationship between PM2.5 exposure and PTB has not been investigated.

Objective

This study aimed to assess whether preconception TSH levels modulate the impact of PM2.5 exposure on PTB.

Methods

This cohort study was conducted in Guangdong, China, as a part of the National Free Pre-Pregnancy Checkups Project. PM2.5 exposure was estimated by using the inverse distance weighting method. To investigate the moderating effects of TSH levels on trimester-specific PM2.5 exposure and PTB, we used the Cox proportional hazards model. Additional

SUBMITTER: Xu T 

PROVIDER: S-EPMC11310741 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature