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Versatile dehydrogenation of carbonyls enabled by an iodine(III) reagent.

ABSTRACT: We report the utilisation of an iodine(III) reagent to access α,β-unsaturated carbonyls from the corresponding silyl enol ethers of ketones and aldehydes, and from enol phosphates of lactones and lactams. The transformation is rapid, scalable, and can be carried out in one pot, directly dehydrogenating saturated carbonyls.

SUBMITTER: Botlik BB

PROVIDER: S-EPMC11310745 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature

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Versatile dehydrogenation of carbonyls enabled by an iodine(III) reagent.

Botlik Bence B BB Finkelstein Patrick P Paschke Ann-Sophie K AK Reisenbauer Julia C JC Morandi Bill B

Chemical communications (Cambridge, England) 20240822 69

We report the utilisation of an iodine(III) reagent to access α,β-unsaturated carbonyls from the corresponding silyl enol ethers of ketones and aldehydes, and from enol phosphates of lactones and lactams. The transformation is rapid, scalable, and can be carried out in one pot, directly dehydrogenating saturated carbonyls. ...[more]

PMID: 39118590

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