Pharmacogenetic Variants and Plasma Concentrations of Antiseizure Drugs: A Systematic Review and Meta-Analysis.

ABSTRACT:

Importance

Precise estimation of a patient's drug metabolism capacity is important for antiseizure dose personalization.

Objective

To quantify the differences in plasma concentrations for antiseizure drugs associated with variants of genes encoding drug metabolizing enzymes.

Data sources

PubMed, Clinicaltrialsregister.eu, ClinicalTrials.gov, International Clinical Trials Registry Platform, and CENTRAL databases were screened for studies from January 1, 1990, to September 30, 2023, without language restrictions.

Study selection

Two reviewers performed independent study screening and assessed the following inclusion criteria: appropriate genotyping was performed, genotype-based categorization into subgroups was possible, and each subgroup contained at least 3 par

SUBMITTER: Milosavljevic F 

PROVIDER: S-EPMC11310823 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature