Oral Antibiotics and Risk of Serious Cutaneous Adverse Drug Reactions.

ABSTRACT:

Importance

Serious cutaneous adverse drug reactions (cADRs) are potentially life-threatening drug hypersensitivity reactions involving the skin and internal organs. Antibiotics are a recognized cause of these reactions, but no studies have compared relative risks across antibiotic classes.

Objectives

To explore the risk of serious cADRs associated with commonly prescribed oral antibiotics, and to characterize outcomes of patients hospitalized for them.

Design, setting, and participants

Nested case-control study using population-based linked administrative datasets among adults aged 66 years or older who received at least 1 oral antibiotic between 2002 and 2022 in Ontario, Canada. Cases were those who had an emergency department (ED) visit or hospitalization for seriou

SUBMITTER: Lee EY 

PROVIDER: S-EPMC11310841 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature