Genome-wide association study of delay discounting in Heterogeneous Stock rats.

ABSTRACT: Delay discounting refers to the behavioral tendency to devalue rewards as a function of their delay in receipt. Heightened delay discounting has been associated with substance use disorders and multiple co-occurring psychopathologies. Human and animal genetic studies have established that delay discounting is heritable, but only a few associated genes have been identified. We aimed to identify novel genetic loci associated with delay discounting through a genome-wide association study (GWAS) using Heterogeneous Stock (HS) rats, a genetically diverse outbred population derived from eight inbred founder strains. We assessed delay discounting in 650 male and female HS rats using an adjusting amount procedure in which rats chose between smaller immediate sucrose rewards or a larger reward at v

SUBMITTER: Lara MK 

PROVIDER: S-EPMC11310854 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature