Prognostic and immunotherapeutic significances of M2 macrophage-related genes signature in lung cancer.

ABSTRACT: Objective: We aimed to investigate the immunological significance of M2 macrophage-related genes in lung cancer (LC) patients, specifically focusing on constructing a risk score to predict patient prognosis and response to immunotherapy. Methods: We developed a novel risk score by identifying and incorporating 12 M2 macrophage-related genes. The risk score was calculated by multiplying the expression levels of risk genes by their respective coefficients. Through comprehensive enrichment analysis, we explored the potential functions distinguishing high- and low-risk groups. Moreover, we examined the relationship between patients in different risk groups and immune infiltration as well as their response to immunotherapy. The single-cell RNA sequencing data were acquired to asce

SUBMITTER: Wu H 

PROVIDER: S-EPMC11310876 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature