Hexagonal Plasmonic Arrays for High-Throughput Multicolor Single-Molecule Studies.

ABSTRACT: Nanophotonic biosensors offer exceptional sensitivity in the presence of strong background signals by enhancing and confining light in subwavelength volumes. In the field of nanophotonic biosensors, antenna-in-box (AiB) designs consisting of a nanoantenna within a nanoaperture have demonstrated remarkable single-molecule fluorescence detection sensitivities under physiologically relevant conditions. However, their full potential has not yet been exploited as current designs prohibit insightful correlative multicolor single-molecule studies and are limited in terms of throughput. Here, we overcome these constraints by introducing aluminum-based hexagonal close-packed AiB (HCP-AiB) arrays. Our approach enables the parallel readout of over 1000 HCP-AiBs with multicolor single-molecule sensiti

SUBMITTER: Herkert EK 

PROVIDER: S-EPMC11310910 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature