Key genes and immune infiltration patterns and the clinical implications in psoriasis patients.

ABSTRACT:

Background

Psoriasis is an immune-mediated skin disease, closely related to immune regulation. The aim was to understand the pathogenesis of psoriasis further, reveal potential therapeutic targets, and provide new clues for its diagnosis, treatment, and prevention.

Materials and methods

Expression profiling data were obtained from the Gene Expression Omnibus (GEO) database for skin tissues from healthy population and psoriasis patients. Differentially expressed genes (DEGs) were selected for Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and Gene Set Enrichment Analysis (GSEA) analysis separately. Machine learning algorithms were used to obtain characteristic genes closely associated with psoriasis. Receiver operating characteristic (ROC) curve was used

SUBMITTER: Zhang X 

PROVIDER: S-EPMC11311119 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature