Development of Continuous Additive-Controlled MSMPR Crystallization by DoE-Based Batch Experiments.

ABSTRACT: Additive-controlled crystallization is a promising method to improve crystal morphology and produce solid drug particles with the desired technological and pharmacological properties. However, its adaptation to continuous operation is a hardly researched area. Accordingly, in this work, we aimed to come up with a methodology that provides the systematic and fast development of a continuous three-stage MSMPR cascade crystallizer. For that, a cooling crystallization of famotidine (FMT) from water, in the presence of a formulation additive, poly(vinylpyrrolidone) (PVP-K12), was developed. Process parameters with a significant impact on product quality and quantity were examined in batch mode through a 2^4-1 fractional factorial design for the implementation of additive-controlled co

SUBMITTER: Stoffan GN 

PROVIDER: S-EPMC11311132 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature