Astrocyte Mitochondria Are a Sensitive Target of PCB52 and its Human-Relevant Metabolites.

ABSTRACT: Polychlorinated biphenyls (PCBs) are industrial chemicals that are ubiquitously found in the environment. Exposure to these compounds has been associated with neurotoxic outcomes; however, the underlying mechanisms for such outcomes remain to be fully understood. Recent studies have shown that astrocytes, the most abundant glial cell type in the brain, are susceptible to PCB exposure as well as exposure to human-relevant metabolites of PCBs. Astrocytes are critical for maintaining healthy brain function due to their unique functional attributes and positioning within the neuronal networks in the brain. In this study, we assessed the toxicity of PCB52, one of the most abundantly found PCB congeners in outdoor and indoor air, and two of its human-relevant metabolites, on astrocyte mitochondr

SUBMITTER: Paranjape N 

PROVIDER: S-EPMC11311133 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature