Role of ATG4 Autophagy-Related Protein Family in the Lower Airways of Patients with Stable COPD.

ABSTRACT: Autophagy is a complex physiological pathway mediating homeostasis and survival of cells degrading damaged organelles and regulating their recycling. Physiologic autophagy can maintain normal lung function, decrease lung cellular senescence, and inhibit myofibroblast differentiation. It is well known that autophagy is activated in several chronic inflammatory diseases; however, its role in the pathogenesis of chronic obstructive pulmonary disease (COPD) and the expression of autophagy-related genes (ATGs) in lower airways of COPD patients is still controversial. The expression and localization of all ATG proteins that represented key components of the autophagic machinery modulating elongation, closure, and maturation of autophagosome membranes were retrospectively measured in peripheral l

SUBMITTER: Nucera F 

PROVIDER: S-EPMC11311497 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature