Sex-Dependent T Cell Dysregulation in Mice with Diet-Induced Obesity.

ABSTRACT: Obesity is an emerging public health problem. Chronic low-grade inflammation is considered a major promotor of obesity-induced secondary diseases such as cardiovascular and fatty liver disease, type 2 diabetes mellitus, and several cancer entities. Most preliminary studies on obesity-induced immune responses have been conducted in male rodents. Sex-specific differences between men and women in obesity-induced immune dysregulation have not yet been fully outlined but are highly relevant to optimizing prevention strategies for overweight-associated complications. In this study, we fed C57BL/6 female vs. male mice with either standard chow or an obesity-inducing diet (OD). Blood and spleen immune cells were isolated and analyzed by flow cytometry. Lean control mice showed no sex bias in syste

SUBMITTER: Brummer C 

PROVIDER: S-EPMC11311663 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature