A Scaled Proteomic Discovery Study for Prostate Cancer Diagnostic Markers Using Proteograph^TM and Trapped Ion Mobility Mass Spectrometry.

ABSTRACT: There is a significant unmet need for clinical reflex tests that increase the specificity of prostate-specific antigen blood testing, the longstanding but imperfect tool for prostate cancer diagnosis. Towards this endpoint, we present the results from a discovery study that identifies new prostate-specific antigen reflex markers in a large-scale patient serum cohort using differentiating technologies for deep proteomic interrogation. We detect known prostate cancer blood markers as well as novel candidates. Through bioinformatic pathway enrichment and network analysis, we reveal associations of differentially abundant proteins with cytoskeletal, metabolic, and ribosomal activities, all of which have been previously associated with prostate cancer progression. Additionally, optimized machin

SUBMITTER: Chang MEK 

PROVIDER: S-EPMC11311733 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature