Advancements in Research and Treatment Applications of Patient-Derived Tumor Organoids in Colorectal Cancer.

ABSTRACT: Colorectal cancer (CRC) remains a significant health burden globally, being the second leading cause of cancer-related mortality. Despite significant therapeutic advancements, resistance to systemic antineoplastic agents remains an important obstacle, highlighting the need for innovative screening tools to tailor patient-specific treatment. This review explores the application of patient-derived tumor organoids (PDTOs), three-dimensional, self-organizing models derived from patient tumor samples, as screening tools for drug resistance in CRC. PDTOs offer unique advantages over traditional models by recapitulating the tumor architecture, cellular heterogeneity, and genomic landscape and are a valuable ex vivo predictive drug screening tool. This review provides an overview of the current li

SUBMITTER: van der Graaff D 

PROVIDER: S-EPMC11311786 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature