Venom Ex Machina? Exploring the Potential of Cell-Free Protein Production for Venom Biodiscovery.

ABSTRACT: Venoms are a complex cocktail of potent biomolecules and are present in many animal lineages. Owed to their translational potential in biomedicine, agriculture and industrial applications, they have been targeted by several biodiscovery programs in the past. That said, many venomous animals are relatively small and deliver minuscule venom yields. Thus, the most commonly employed activity-guided biodiscovery pipeline cannot be applied effectively. Cell-free protein production may represent an attractive tool to produce selected venom components at high speed and without the creation of genetically modified organisms, promising rapid and highly efficient access to biomolecules for bioactivity studies. However, these methods have only sporadically been used in venom research and their potenti

SUBMITTER: Paas A 

PROVIDER: S-EPMC11311792 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature