Get Spliced: Uniting Alternative Splicing and Arthritis.

ABSTRACT: Immune responses demand the rapid and precise regulation of gene protein expression. Splicing is a crucial step in this process; ~95% of protein-coding gene transcripts are spliced during mRNA maturation. Alternative splicing allows for distinct functional regulation, as it can affect transcript degradation and can lead to alternative functional protein isoforms. There is increasing evidence that splicing can directly regulate immune responses. For several genes, immune cells display dramatic changes in isoform-level transcript expression patterns upon activation. Recent advances in long-read RNA sequencing assays have enabled an unbiased and complete description of transcript isoform expression patterns. With an increasing amount of cell types and conditions that have been analyzed with s

SUBMITTER: van Haaren MJH 

PROVIDER: S-EPMC11311815 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature